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This report describes opposing effects of synaptic compared with extrasynaptic NMDARs on BDNF expression and cell survival: the activation of synaptic NMDARs led to upregulation of BDNF expression and the activation of extra-synaptic NMDARs reduced BDNF expression

Supplement Smartly if Needed: As mentioned, supplements like N-acetylcysteine (NAC) can help supply the raw material for glutathione

Also, many studies are short-term with small groups

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Kelley DE, He J, Menshikova EV, Ritov VB

However, much less attention has been paid by medicinal chemists to the field of developing brain targeting drug delivery systems or organ targeting drug delivery systems in a more general perspective via modification of an existing drug delivery system