R471C has been shown to localise to the membrane and has ~15% activity of wildtype OCTN2 in CHO cells, which is consistent with the observed reduction in currents for R471A, meanwhile Y358N in CHO cells has ~8% activity, though localisation data for Y358N is unavailable 11,50
Muntz FH
Acetyl-L-carnitine is involved in protein acetylation Development, Cell Differentiation and Cancer 1996, 9th International Conference ISD, Pisa, Italy Swamy-Mruthinti S, Carter AL
Patients considering glutathione treatment should understand both mechanism and evidence quality before starting
I still get headaches now and then, but ibuprofen takes care of it- which it never did before
Irwin C, McCartney D, Desbrow B, Khalesi S