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The compounds GCGR component raises basal energy expenditure and promotes hepatic fat clearance

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In a randomized controlled trial, the GLP-1R agonist exenatide showed reduced alcohol intake in a subgroup of people with both obesity and alcohol use disorder

To account for potential pleiotropy, in each analysis, we used different analytic methods robust to pleiotropy, including Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO), a weighted median, and weighted mode

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Enrolled participants were randomized to receive 3 mg, 7 mg, or 14 mg of oral semaglutide or placebo once daily for 52 weeks