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In POF animal models, induced by drugs, radiotherapy, or heavy metals, resveratrol significantly promotes primordial follicle activation, increases the number of primary, primordial, and growing follicles, stimulates GC proliferation, diminishes ovarian inflammation, maintains ovarian architecture, and rescues oocyte and GC apoptosis (Said et al., 2016

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[11] Pyridoxine has been extensively used to treat nausea and vomiting of pregnancy, reflecting its safety profile

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