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Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)

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Although, light activities such as reading a book, newspaper or mobile phone surfing were allowed

These findings strengthen the hypothesis that Epitalons chronobiotic activity extends beyond hormonal stimulation because it may also preserve the structural and cellular integrity of the pineal gland as we age [57]

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