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It is produced primarily in the liver and is involved in many critical biological functions in the body including metabolism of toxins, immune system function, protection against oxidative cell damage, and recycling of vitamins E and C
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In diabetes, this balance is disrupted, shifting towards excessive fission and resulting in mitochondrial fragmentation and functional impairment (Sun et al., 2021)
& Spitz, D
These mechanisms involve modifications to the membranes lipid bilayer structure, the creation of membrane pores that impair barrier function, a decrease in membrane thickness, and alterations in permeability ( Lipid peroxidation serves as a crucial mechanism in ferroptosis, and its occurrence within the bone microenvironment significantly contributes to cellular ferroptosis, thereby impacting bone health
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