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GLP-1R signaling regulates brain energy homeostasis and may improve mitochondrial function in depression In addition to the disturbed neuroimmune and neuroendocrine crosstalk, disruptions in brain metabolism and mitochondrial functions seem to be an emergent field of interest in the context of depression pathogenesis

Metabolic factors influencing menstrual function during weight loss: Leptin levels: This adipocyte-derived hormone decreases with fat loss and plays a crucial role in reproductive function signaling Insulin sensitivity: Improved insulin sensitivity can normalize androgen levels, particularly beneficial in PCOS Inflammatory markers: Reduction in chronic low-grade inflammation associated with obesity Sex hormone-binding globulin (SHBG): Levels typically increase with weight loss, affecting free hormone availability For women with obesity-related reproductive dysfunction, particularly those with PCOS, moderate and sustained weight loss often improves menstrual regularity over time

Efectos gastrointestinales: Los efectos adversos ms comunes son de naturaleza gastrointestinal e incluyen nuseas (reportadas en 20-40% de los pacientes), vmitos, diarrea y estreimiento

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