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Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling

Here's a breakdown of how it works: 1

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As per the researchers, Tesamorelin is a synthetic growth hormone-releasing hormone that acts on the anterior pituitary gland to stimulate the endogenous growth hormone secretion. (6) Studies suggest that the peptide may potentially cause a 69% increase in total growth hormone levels (apparently assessed via area under the curve - AUC) and a purported 55% increase in the mean pulse area of the growth hormone

10.1016/j.bbrc.2016.02.019 90

Adjusting protein slightly upward, reassessing total calories, or adding a week of lower-intensity fasting before resuming often breaks through it