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Retatrutide vs Tirzepatide: Next-Generation Weight Loss Medications Last Updated: February 2026 11 min read Key Takeaways Retatrutide is an investigational triple hormone agonist (GLP-1, GIP, and glucagon) showing 24% average weight loss in trials, while tirzepatide is FDA-approved with proven 21% weight loss
J Biol Chem 1993
Cancer has returned after treatment
mean 20.440.5 vs 5.69.3 h
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