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Expansion Across Key Indication Obesity / Weight Management: Orforgliprons Phase III trial ATTAIN-1 in non-diabetic obese or overweight adults (with weight-related medical conditions) showed clinically meaningful weight loss (up to ~12.4%) vs placebo over ~72 weeks
It defined individual distinct RCD modalities, including intrinsic and extrinsic apoptosis, autophagy-dependent cell death, entotic cell death, ferroptosis, lysosome-dependent cell death, mitochondrial permeability transition-driven necrosis, mitotic death, necroptosis, NETotic cell death, parthanatos, and pyroptosis [4]
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Enzymatic and Chemical Synthesis for ADP-Ribosylation Using NAD(+) as Building Blocks: New Concerns in Reaction Discovery and Design
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