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Some preliminary work in this area exists

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Fatigue and headache The most consistent community feedback for the first week is brief headache and mild fatigue, fading within 7-10 days

For patients asking about skin texture, firmness, fine lines, or scalp support, topical GHK-Cu is the route we are comfortable discussing in a medical aesthetics setting

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That's a meaningful body of circumstantial evidence, but it's not the same as clinical proof of efficacy in humans