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Probably the game-changing study in the New England Journal, which I was corresponding author on, was STEP 1, which actually launched semaglutide to the world which for the first time caused a result in a 15% weight loss at the end of a year

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Two samples were removed from vehicle group, i.e., one sample was non-detectable and for another sample the activity was a significant outlier (Grubbs test)

Oral semaglutide produces nausea in roughly 20-30% of patients versus 25-45% for injectionsa modest reduction

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