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Proanthocyanidins/bioflavonoids are a class of naturally-occurring, water-soluble polyphenolic compounds that are found in plants

MOTS-c activates AMPK by disrupting the folate cycle, specifically by inhibiting AICAR transformylase, an enzyme in the de novo purine synthesis pathway

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Statistical significance was assessed using two-tailed unpaired t-tests with false discovery rate (FDR) correction using the two-stage step-up method of Benjamini, Krieger and Yekutieli (Q = 1%)