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In 1999, James and coworkers reported increased plasma hcy levels and an increased frequency of both MTHFR 677CT and TT genotypes in mothers of DS individuals (MDS) with respect to control mothers, and that paper opened the way to the study of folate gene polymorphisms as maternal risk factors for the birth of a child with DS (James et al., 1999)

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% T / C was calculated by dividing the median treated tumour weight by the median control tumour weight and multiplying by 100 on the last day of treatment

Initially, Safe B12 injection dosage for adults is usually administered 1-3 times per week

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Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection