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Any failure to repair DSBs could lead to gross chromosomal rearrangements, neoplastic transformation of cells, and oncogenesis 1

The analysis of two randomised, placebo-controlled trials showed that acetyl-l-carnitine reduced pain and improved nerve regeneration and vibration perception in patients with diabetes treated with 500 or 1000 mg/day of the drug [66]

But "not contraindicated" is different from "safe and risk-free." Here is a practical framework based on the pharmacology and clinical evidence

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