Type 2 Diabetes (since 2009) Obesity treatment (since 2014) Cardiovascular outcomes and kidney trials ongoing Current research includes Alzheimers trials and other neurocognitive disorders | | Drug Examples: Liraglutide , Semaglutide | These GLP-1 receptor agonists are now being studied for their potential to cross the blood-brain barrier and exert neuroprotective effects, possibly mitigating oxidative stress and mitochondrial dysfunction associated with neurodegenerative diseases
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It upregulates genes involved in repair, antioxidant defense, and stem cell function while downregulating genes associated with inflammation, fibrosis, and tissue destruction
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Source data files for pharmacological experiments are available as a Supplementary Information Excel file included with this manuscript
