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Oral supplementation works because approximately 1% of an oral dose is absorbed through passive diffusion, bypassing the need for intrinsic factor

These observations have prompted interest in its relevance to experimental models of intestinal barrier impairment

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Number of reactions per 10,000 doses sold between 2010-2014 (that were reported), please note that some people do not record adverse reactions so numbers could be significantly higher: Dogs Cats Allergic conditions 2663 187 Anaphylaxis 332 29 Dyspnea 155 110 Vomiting 2511 1131 Diarrhoea 791 402 Loss of consciousness 141 8 Pain 240 176 Lethargy 1923 1473 Fever 132 438 Malaise 17 17 Vasculitis 13 1 Cough 445 16 Respiratory disorders 346 85 Injection site reaction 1144 689 Injection site sarcoma 2 148 Death 104 161 Suspected lack of efficacy 228 39 Neurological disorders 459 249 Autoimmune disorders 27 8 It again is highlighted that protective and susceptible gene halotypes have been identified in dogs demonstrating genetic predispositions to hypersensitivities and adverse reactions to vaccinations