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For the narrower MACE-3 composite of cardiovascular death, myocardial infarction, or stroke, 27 events occurred among participants receiving retatrutide compared with 23 in the placebo group, resulting in a hazard ratio of 1.12 (95% CI: 0.64-1.96)

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Indirect comparisons suggest that injectable semaglutide (Ozempic) produces slightly greater weight loss and improvements in blood sugar than oral semaglutide (Rybelsus)