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In a phase 1b trial, 20 weeks of cagrilintide 2.4 mg once weekly in combination with semaglutide 2.4 mg once weekly (cagrisema) resulted in up to 17.1% WL compared to 9.5% WL with semaglutide 2.4 mg plus placebo in people with obesity [88]

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Electron-accepting micelles deplete reduced nicotinamide adenine dinucleotide phosphate and impair two antioxidant cascades for ferroptosis-induced tumor eradication

HuangT-YSongW-XWangY-SLiuYChenF-JChenY-Het al

[4] Fasting blood glucose and random glucose measurements provide additional information about day-to-day glycemic control

Peer review Peer review information Nature Reviews Drug Discovery thanks Michael Nauck, Stefan Trapp and the other, anonymous, reviewer(s) for their contribution to the peer review of this work