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The timeline varies based on the type of injury studied, the dose used, the route of administration, and the animal model

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Whole-cell patch-clamp recordings were performed on mRFP--actin-transfected hippocampal neurons to measure miniature excitatory postsynaptic currents (mEPSCs), reflecting synaptic activity [1]

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The combination could theoretically increase penetration or sensitivity for some models

PMID: 21030666 Kang EA, et al