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doi: 10.1056/NEJMoa2511774

The DEGs with known function that are positively regulated by Cyss deprivation in an NRF2-dependent manner are stress response genes involved in endoplasmic reticulum (ER) stress response and autophagy ( DDIT4 , CREB3L4 , DDIT3 , XAF1 , NUPR1, and GADD45B ) [32,33,34,35,36], mitophagy ( MORN4 ) [37] or mitochondrial biogenesis ( TFB1M ) [38]

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The need for new treatments targeting mpnst: the potential of strategies combining mek inhibitors with antiangiogenic agents