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Interest broadened sharply after Yang and colleagues (Cell, 2014) used targeted metabolomic profiling across twelve ferroptosis-inducing small molecules and found that glutathione depletion converges on inactivation of the selenoenzyme glutathione peroxidase 4, placing glutathione availability directly upstream of iron-dependent lipid peroxidation

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Increased eryptosis in patients with primary antiphospholipid syndrome (APS): a new actor in the pathogenesis of APS

Food Chem Toxicol 155:112406

Chemosphere 82:483487

doi:10.1136/thx.2005.048512