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Ex4-d-Ala is represented as orange ribbon (backbone) and sticks (side chains, position 4 as thick stick), and GLP-1R is represented as white ribbon

In recent years, a class of medications known as GLP-1 receptor agonists (GLP-1s) has gained tremendous attention

However, as the popularity of GLP-1 drugs has surged, so have reports of serious side effects, such as stomach paralysis, intestinal obstructions and vision loss

PAPs are harder to qualify for (strict income limits and medical criteria), but if you do qualify, you might receive the medication free or at a very low cost

Executive Vice President & President, Lilly Cardiometabolic Health, Eli Lilly and Company Why this matters 1 Triple agonist = next-gen metabolic therapy Mimics GLP-1, GIP, and glucagon multi-pathway metabolic control 2 Diabetes + obesity convergence Simultaneous A1C + weight control = major unmet need solved 3 Competitive landscape shift Raises the bar vs GLP-1 mono & dual incretin therapies 4 No plateau signal is critical Suggests longer-term sustained efficacy Safety profile (expected class effects) Nausea, diarrhea, vomiting (dose-escalation phase) Discontinuation rates relatively low (25%) My takeaway 1 Metabolic disease treatment is entering multi-hormone era 2 Obesity + diabetes becoming one therapeutic category 3 Efficacy approaching bariatric-level outcomes 4 Sets new benchmark for Novo Nordisk and competitors Bottom line: Retatrutide isnt just competing Its redefining how we treat metabolic disease at the systems level #Diabetes #Obesity #GLP1 #Biotech #ClinicalTrials #Pharma #Innovation To view or add a comment, sign in 2,744 followers

Different types of GLP-1 drops and how each one works Not all GLP-1 drops are identical