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442 Research into ketamine actions in the CNS revealed multiple effects, including potentiation of synaptogenesis, increased density of dendritic spines and upregulation of postsynaptic levels of AMPA receptors

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Cagrilintide Phase 2 monotherapy (Lau et al., Lancet 2021) reported about 10.8% weight loss at 26 weeks at 4.5 mg