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Nevertheless, their therapeutic potentials are still subject of debate, particularly given their known gastrointestinal side effects (e.g., nausea, vomiting, and diarrhea), which may limit their application in IBD patients, especially those with clinically active disease (14)

They conducted a meta-analysis of 11 large-scale clinical trials of GLP-1 receptor agonists involving a total of 85,373 people

In our study, we systematically demonstrated that ACTL6A inhibited GC cell ferroptosis by promoting GSH synthesis through upregulating GCLC

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10.1093/nar/gkw836 92 WangC.Wilson-BerryL.SchedlT.HansenD

In the context of peptides for senior dogs research, this tolerability profile supports BPC-157 as a compound suitable for extended observation windows without significant safety concern at research doses