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The longest trials conducted on semaglutide have spanned two years
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In RGCs, a diverse group of neurons found in the inner retinal surface with long axons that connect to the brain to relay visual information, neurodegeneration is also seen and, in fact, may precede changes in microvasculature in DR [85]
While this effect may still be clinically relevant in reducing concerns about post-cessation weight gain, the results should be interpreted with caution, given the small number of available studies and the low-to-very-low certainty of evidence
J.PaimanE
Li B, Yamamori H, Tatebayashi Y, Shafit-Zagardo B, Tanimukai H, Chen S, et al
From a chemical perspective, it is a modified GLP-1 analogue built from 31 amino acids, whose structure has been designed to increase enzymatic stability and prolong action time
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