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Moreover, the use of evidence synthesis, using recommended methodologies, is becoming increasingly important and accepted for health technology assessment globally [59, 60]

When adding a GLP-1 receptor agonist, clinicians may reduce insulin or sulfonylurea doses to lower the risk of hypoglycaemia

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Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Carcinogenesis A two-year carcinogenicity study was conducted in CD-1 mice with doses of 0.2, 0.5, and 1.2 mg/kg/day of pramlintide (32, 67, and 159 times the exposure resulting from the human dose of 360 mcg/day based on area under the plasma concentration curve or AUC, respectively)