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Acetylcarnitine, on the other hand, affects the epigenetic regulation of metabotropic glutamate type 2 receptors (mGluR2), negatively modulating neurotransmitter release and producing rapid and long-lasting antidepressant effects (demonstrated by forced swim tests, sucrose preference tests) in Flinders Sensitive Line rats and in mice exposed to chronic unpredictable stress, which model genetic and environmentally induced depression, respectively [92]

277, R1537R1540

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The biological plausibility can assess whether there is a mechanism to support the potential relationship between ADRs and the studied drug

89 Conventionally, GDH (coded by the GLUD gene) is the more predominant enzymes vital for the reactions needed to replenish the TCA cycle and yield NADPH than GOT2 and GPT2, which consists of ubiquitously expressed GDH1 and GDH2 mainly existing in neuronal and testicular tissue and having lower activity than GDH1