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Several pts with mild mood disorders have had ramped up manic behaviors that coincided with the GLP meds start

weight loss lowers estrogen levels, leading to temporary cycle changes like irregularity or amenorrhea in some women

Tocochromanols, along with bile acids and products of fat digestion, are incorporated into micelles, and the contents are taken up by intestinal cells (enterocytes)

But in the context of comprehensive treatment, theyre quite effective

Taking the medication with food, staying hydrated, eating smaller portions, and using anti-nausea medication during peak weeks (6-8) dramatically improves tolerability

Injections with higher efficacy and longer-acting are more fit for longer-term use both for diabetic and non-diabetic patients