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Nitrate supplementation resulted in reduced oxygen uptake (VO 2 ) at moderate and severe intensities and a reduced VO 2 at the time of exhaustion ( 2 at the time of exhaustion, there was a statistically significant increase in time to exhaustion

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Under physiological conditions, ROS are generated in the heart mainly from the mitochondrial electron transport chain, nitric oxide synthases (NOS), NADPH oxidases (NOX), and xanthine oxidase (XO) in small quantities [7, 8]

Oxidative Medicine and Cellular Longevity 2016: 7432797