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After intravenous administration, the agents enter the systemic circulation and rapidly undergo covalent binding to plasma biomacromolecules within a short period, with human serum albumin (HSA) as the primary binding target
Diuretics Loop diuretics (furosemide, bumetanide) and thiazides reduce effective circulating volume, which lowers GFR in a dose-dependent fashion
Popawski PT et al
Trib1 D355 makes a salt bridge with COP1 K472 and Trib1 Y361 forms a hydrogen bonding with COP1 H578 (Fig
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