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While the weight-loss data for semaglutide are encouraging, to really get the cardiologists excited about prevention and weight loss, especially addressing weight loss in the context of a cardiovascular visit, what is needed are CV outcomes trials that show meaningful outcomes differences, Neeland said in an interview

Fatigue and weakness often accompany the initial weeks of treatment, partially due to reduced caloric intake as appetite decreases

This approach allows for repurposing of approved drugs and may improve potency by invoking multiple mechanisms of action

However, if you drink alcohol while on semaglutide, there is a potential for worsening gastrointestinal side effects