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In a study with more than 6,000 people participating in one of two weight loss programs, those on a 500 calorie per day diet for three months, followed by nine months of weight maintenance, were three times more likely to need hospitalization for symptomatic gallstones or cholecystectomy for gallstones than those who started with a 1,2001,500 calorie per day diet

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10.1038/jcbfm.2013.135 J

Results were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI)