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In the retatrutide Phase 2 trial (Jastreboff et al., NEJM 2023), many participants found that symptoms such as diarrhoea, nausea, and abdominal discomfort improved after the initial weeks at a given dose, consistent with experience seen with licensed GLP-1 receptor agonists
Pizzimenti S, Ciamporcero E, Daga M, Pettazzoni P, Arcaro A, Cetrangolo G et al
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Myth: Everyone Needs Weekly Injections Many people think B12 shots are only for those with a diagnosed deficiency, but thats not the whole story