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Methamphetamine behaves as both a weak substrate and competitive inhibitor of CYP2D6, while MDMA acts as a high affinity substrate and potent mechanism-based inhibitor (MBI) of the enzyme
These two are best used in whitening the skin
No standardized long-term maintenance schedule exists in published literature
Effects develop over 37 days and typically last 34 months
Given that several membrane barriers need to be crossed, transcellular transport is generally expected to require more time compared to extracellular transport
R.CozzolinoF.RotilioG.et al
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