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These mechanisms can contribute to the development of atherosclerosis, myocardial injury and coronary heart disease (35)

Table 3 Group differences in % change from previous timepoint including timepoints 1, 2, and 3 (main effects for the group)

Dose reduction for side effects If a dose increase triggers side effects that do not improve after two to three weeks, stepping back down to the previous dose is the standard approach

These products may be unsafe or ineffective and should be avoided

Constipation Some people experience the opposite effect, with difficulty passing stool

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