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It is, however, important to acknowledge the other side of the coin: the GLP-1 RAs are associated with rapidly increasing expenditures [15], the use of falsified drugs [16, 17], and adverse events such as gastrointestinal adverse events which may be investigated more in the future along with the increased use of the GLP-1 RAs [18, 19]

TABLE 1 Incretin therapy studies including percentage of participants who failed to reach the desired endpoint

Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes

The role of metallobiology and amyloid- peptides in Alzheimers disease

Stoeckius, M

, J