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Opioids In animal models, several GLP-1R agonists have been shown to reduce self-administration and relapse behavior for heroin, fentanyl, and oxycodone

Moreover, offering oral GLP1 options allows primary care providers to meet patient preferences without compromising efficacy

doi: 10.1016/j.molmet.2019.09.010 11 LeeY-SJunH-S

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Until recently, therapeutic strategies remained limited to lifestyle interventions, with few pharmacological options demonstrating meaningful clinical benefit