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The group targeting a 4 mg maintenance dose simply started at 2 mg for 4 weeks and then increased to 4 mg

[cited 2024 Jan 19]

Think of it as training for a marathon rather than sprinting out of the gate

Nausea may intensify with each dose increase

These effects were more noticeable in longer trials and when ALA was combined with dietary changes.29 A 2020 dose-response meta-analysis confirmed small but statistically significant reductions in weight and BMI across 18+ randomized controlled trials.30 However, waist circumference (WC) a marker of central obesity showed no consistent change, and the benefit appeared greater in women and with longer treatment durations

Epub 2023 Apr 16