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Animal models show this peptide induces concentration-dependent vasodilation, an effect that was diminished when NO synthesis was inhibited

GLP-1 RAs are first-choice medications [archived link] to help adults achieve (and maintain) weight loss

Adjusting Your GLP-1 Treatment to Reduce Headaches If headaches persist beyond the initial adjustment period or significantly impact your quality of life, discuss dose modification strategies with your prescribing clinician