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The PlexusDx Precision Peptide Genetic Test analyzes 49 peptides across 14 pathways, including GIPR rs1800437, FTO rs9939609, and MC4R rs17782313genes that influence semaglutide metabolism and efficacy

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Adverse events were mild to moderate in severity, most commonly gastrointestinal disturbance (207 adverse events, 37%), with similar rates across treatment groups

725-33, DOI:10.1111/j.1440-1681.2006.04425.x, PMID 16895547

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Their impact is aggravated by their chronicity and comorbidity and the insufficient efficacy of current treatments