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Nearly all liver-specific Gclc L-KO mice survived over time (Fig

However, a major limitation of macrophage-reprogramming strategies lies in the extreme plasticity of TAMs and high tumor heterogeneity, which can cause reprogrammed M1 macrophages to revert to an M2 state

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Moreover, SLC25A40 has been implicated in ovarian and breast cancer 35,36 , and cancer resistance in human leukemia K562 cells 37 , suggesting that transporter-specific control of mtGSH may have broader implications for inflammatory and mitochondrial diseases