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A 2020 study of "wellness" B12 injections in non-deficient adults found no improvement in energy, mood, or cognitive function versus placebo at 4 weeks (Wolffenbuttel et al., Nutrients , 2020)
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Growing evidence shows that modulation of the intracellular -ketoglutarate levels could constitute an important mechanism of metabolic control that can also interfere with many physiological processes [6, 20]
Such studies may help clarify how structural organization emerges from the interaction of cellular, molecular, and extracellular factors across multiple tissue types
