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Furthermore, based on preclinical evidence suggesting that muscle-derived IL-6 may enhance postprandial GLP-1 secretion [90], it has been proposed that GLP-1RAs could modulate metabolic and inflammatory processes through this pathway [39]
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Understanding this relationship helps clinicians counsel patients appropriately and distinguish between expected medication effects and symptoms requiring further investigation
The arcuate nucleus contains two opposing neuronal types: appetite-stimulating neurons (expressing neuropeptide Y and agouti-related peptide) and appetite-suppressing neurons (expressing pro-opiomelanocortin and cocaine- and amphetamine-regulated transcript)
Bioactivity was determined using an IGF-1-responsive firefly luciferase reporter assay
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