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Hands and feet that feel persistently cold while the face feels warm or flushed

Developed by Eli Lilly under the compound code LY3437943, retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors a mechanism that distinguishes it from currently approved agents such as semaglutide and tirzepatide

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Physicians may prescribe compounded medications as needed to meet medical necessity or drug shortages

More robust human studies will be especially important to validate these findings and explore how microbial changes might affect patient outcomes over time

However, liver function should be monitored during treatment, particularly during dose escalation when the metabolic demands on the liver increase