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Compared to placebo, it has been shown to significantly lower HbA1c by up to 2.07% when administered as a once-weekly subcutaneous injection at a maximum dose of 15 mg
doi: 10.1172/JCI104357 8 HolstJJ
Calder, 2020
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AC system activation generates an increase of the intracellular secondary messenger, cyclic adenosine monophosphate (cAMP), through the conversion of adenosine triphosphate, which then results in the activation of protein kinase A (PKA) and exchange protein activated by cAMP (Epac) [32,33,34,35]
