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This remains an important pharmacological consideration as retatrutide progresses through clinical development, and mechanistic conclusions should be regarded as provisional pending further evidence

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For individuals with IBS-C, the constipating effect of reduced motility can become severe enough to warrant treatment discontinuation

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On one hand, ROS generated by NADPH oxidase 1 (NOX1) and mitochondria can activate RIPK1 and further recruit RIPK3 to initiate necroptosis