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Preclinical studies report approximately 1.6 increases in intracellular NAD+ following NNMT inhibition in adipocyte models
Use with caution in patients with coronary artery disease or a recent MI
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The result is a plasma half-life of approximately 13 hours, supporting once-daily dosing
High-fat meals decrease absorption significantly
While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort
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