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EAE induction Active EAE was induced by subcutaneous immunization with 75 g of MOG 3555 (Charit) emulsified in complete Freunds adjuvant (1:2 dilution, 150 l per mouse), which refers to incomplete Freunds adjuvant (Merck, F5506-10X10ML) enriched with 10 mg ml 1 Mycobacterium tuberculosis (Difco/BD Pharmingen, H37Ra)

TB-4 can also release Ac-SDKP, a smaller peptide studied for anti-scarring and anti-inflammatory effects

Reduced appetite and mild fatigue [1]

Reactive oxygen species: involvement in T cell signaling and metabolism

Diabetes 68 , 11091120 (2019)

Ribeiro, F., Longobardi, I., Perim, P., Duarte, B., Ferreira, P., Gualano, B., Roschel, H., & Saunders, B