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In the UK, the National Institute for Health and Care Excellence (NICE) recommends that semaglutide should be prescribed for weight loss for a maximum of 2 years 24 , but no strict limit is set for tirzepatide 25

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If you are experiencing severe or persistent diarrhea at a given dose level, extending that dose period from 4 weeks to 6 or even 8 weeks before escalating is a legitimate strategy